Nature Communications (Mar 2023)
PIP4K2B is mechanoresponsive and controls heterochromatin-driven nuclear softening through UHRF1
- Alessandro Poli,
- Fabrizio A. Pennacchio,
- Andrea Ghisleni,
- Mariagrazia di Gennaro,
- Margaux Lecacheur,
- Paulina Nastały,
- Michele Crestani,
- Francesca M. Pramotton,
- Fabio Iannelli,
- Galina Beznusenko,
- Alexander A. Mironov,
- Valeria Panzetta,
- Sabato Fusco,
- Bhavwanti Sheth,
- Dimos Poulikakos,
- Aldo Ferrari,
- Nils Gauthier,
- Paolo A. Netti,
- Nullin Divecha,
- Paolo Maiuri
Affiliations
- Alessandro Poli
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Fabrizio A. Pennacchio
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Andrea Ghisleni
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Mariagrazia di Gennaro
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Margaux Lecacheur
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Paulina Nastały
- Laboratory of Translational Oncology, Intercollegiate Faculty of Biotechnology, University of Gdańsk and Medical University of Gdańsk
- Michele Crestani
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Francesca M. Pramotton
- EMPA-Materials Science and Technology
- Fabio Iannelli
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Galina Beznusenko
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Alexander A. Mironov
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Valeria Panzetta
- Department of Chemical, Materials and Production Engineering, University of Naples Federico II
- Sabato Fusco
- Department of Medicine and Health Sciences “V. Tiberio”, University of Molise
- Bhavwanti Sheth
- Inositide Laboratory, School of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton
- Dimos Poulikakos
- Institute for Mechanical Systems, ETH
- Aldo Ferrari
- Institute for Mechanical Systems, ETH
- Nils Gauthier
- IFOM ETS - The AIRC Institute of Molecular Oncology
- Paolo A. Netti
- Department of Chemical, Materials and Production Engineering, University of Naples Federico II
- Nullin Divecha
- Inositide Laboratory, School of Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton
- Paolo Maiuri
- IFOM ETS - The AIRC Institute of Molecular Oncology
- DOI
- https://doi.org/10.1038/s41467-023-37064-0
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 15
Abstract
PIP4Ks are phosphoinositide kinases often dysregulated in cancer. Here Poli and colleagues find that PIP4K2B is downregulated on soft substrates, and its depletion leads to altered nuclear mechanical properties and defects in cell spreading and motility.
