Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses

Anna-Lena Sander; Andres Moreira-Soto; Stoian Yordanov; Ivan Toplak; Andrea Balboni; Ramón Seage Ameneiros; Victor Corman; Christian Drosten; Jan Felix Drexler

doi:10.1038/s42003-022-03421-w

Communications Biology (May 2022)

Genomic determinants of Furin cleavage in diverse European SARS-related bat coronaviruses

Anna-Lena Sander,
Andres Moreira-Soto,
Stoian Yordanov,
Ivan Toplak,
Andrea Balboni,
Ramón Seage Ameneiros,
Victor Corman,
Christian Drosten,
Jan Felix Drexler

Affiliations

Anna-Lena Sander: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Virology
Andres Moreira-Soto: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Virology
Stoian Yordanov: Department of Zoology and Anthropology, Faculty of Biology, Sofia University “St. Kl. Ochridski”
Ivan Toplak: Institute of Microbiology and Parasitology, Virology Unit, Veterinary Faculty, University of Ljubljana
Andrea Balboni: Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna
Ramón Seage Ameneiros: Group Morcegos de Galicia, Drosera Society, Pdo. Magdalena, G-2, 2° esq
Victor Corman: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Virology
Christian Drosten: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Virology
Jan Felix Drexler: Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Institute of Virology

DOI: https://doi.org/10.1038/s42003-022-03421-w
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 8

Abstract

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Genomic analyses of spike glycoprotein genes of European bat SARS-related coronaviruses suggest that furin cleavage sites can be acquired in the bat reservoir via conserved molecular mechanisms, supporting a natural origin of SARS-CoV-2.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal