The Effectiveness of a Bioactive Healing Abutment as a Local Drug Delivery System to Impact Peri-Implant Mucositis: A Prospective Case Series Study
Piotr Wychowański,
Maciej Nowak,
Andrzej Miskiewicz,
Tadeusz Morawiec,
Jarosław Woliński,
Zbigniew Kucharski,
Pier Carmine Passarelli,
Alina Bodnarenko,
Michele Antonio Lopez
Affiliations
Piotr Wychowański
Department of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the “Sacred Heart”, 00168 Rome, Italy
Maciej Nowak
Department of Periodontology and Oral Diseases, Medical University of Warsaw, 6 Binieckiego Street, 02-097 Warsaw, Poland
Andrzej Miskiewicz
Department of Periodontology and Oral Diseases, Medical University of Warsaw, 6 Binieckiego Street, 02-097 Warsaw, Poland
Tadeusz Morawiec
Department of Oral Surgery, Faculty of Medical Sciences in Zabrze, Medical University of Silesia in Katowice, Pl. Akademicki 17, 41-902 Bytom, Poland
Jarosław Woliński
Department of Animal Physiology, The Kielanowski Institute of Animal Physiology and Nutrition, Polish Academy of Sciences, 3 Instytucka Street, 05-110 Jabłonna, Poland
Zbigniew Kucharski
Department of Prosthodontics, Medical University of Warsaw, 6 St. Binieckiego Street, 02-097 Warsaw, Poland
Pier Carmine Passarelli
Department of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the “Sacred Heart”, 00168 Rome, Italy
Alina Bodnarenko
Department of Periodontology and Oral Mucosa Diseases, E. Orzeszkowej 18, 80-208 Gdańsk, Poland
Michele Antonio Lopez
Department of Head and Neck and Sensory Organs, Division of Oral Surgery and Implantology, Institute of Clinical Dentistry, Gemelli Foundation for the University Policlinic, Catholic University of the “Sacred Heart”, 00168 Rome, Italy
Modern dental therapy makes use of prosthetic implant reconstructions, which are supported or retained on dental implants. The most frequent, long-term complications associated with these prosthetic implants include mucositis and peri-implantitis. Since mucositis is the initial inflammation of tissues supporting the dental implant, the management of this condition is thus crucial. The aim of the present study was to assess the effects of the placement of bioactive healing abutment for 48 h, in patients diagnosed with peri-implant mucositis. Moreover, the quantitative and qualitative shift in the bacterial profile of the biofilm present in the peri-implant pockets, was assessed by means of RT-PCR genotyping. Each patient was examined using a commercially available PET test protocol: the first sample was taken upon diagnosis (after which the bioactive healing abutment, with clindamycin at a dose of 30 mg, was used for 48 h and replaced with the prosthetic superstructure used so far by a patient); the second sample was taken two weeks after removal of the bioactive healing abutment. The effects of the intervention were clinically assessed using the PET test after the two weeks. A significant reduction in mucositis was observed following treatment, as measured by periodontal indices: modified Sulcus Bleeding Index—mBI (p p p Aggregatibacter actinomycetemcomitans (p Treponema denticola (p Tannerella forsythia (p Porphyromonas gingivalis (p < 0.132; Z = −1.51).
