Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals

Satvinder Kaur; Roberto De Luca; Mudasir A. Khanday; Sathyajit S. Bandaru; Renner C. Thomas; Rebecca Y. Broadhurst; Anne Venner; William D. Todd; Patrick M. Fuller; Elda Arrigoni; Clifford B. Saper

doi:10.1038/s41467-020-16518-9

Nature Communications (Jun 2020)

Role of serotonergic dorsal raphe neurons in hypercapnia-induced arousals

Satvinder Kaur,
Roberto De Luca,
Mudasir A. Khanday,
Sathyajit S. Bandaru,
Renner C. Thomas,
Rebecca Y. Broadhurst,
Anne Venner,
William D. Todd,
Patrick M. Fuller,
Elda Arrigoni,
Clifford B. Saper

Affiliations

Satvinder Kaur: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
Roberto De Luca: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
Mudasir A. Khanday: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
Sathyajit S. Bandaru: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
Renner C. Thomas: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
Rebecca Y. Broadhurst: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
Anne Venner: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
William D. Todd: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
Patrick M. Fuller: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
Elda Arrigoni: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School
Clifford B. Saper: Department of Neurology, Division of Sleep Medicine, and Program in Neuroscience, Beth Israel Deaconess Medical Center and Harvard Medical School

DOI: https://doi.org/10.1038/s41467-020-16518-9
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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Dorsal raphe 5HT(DRSert) neurons regulate arousal from hypercapnia by their projections to the neurons in the external lateral parabrachial nucleus (PBel) that are glutamatergic and also express calcitonin gene related peptide (PBelCGRP). The DRSert input to the PBel modulates the arousal system to rising levels of blood CO2, and may be mediated by 5HT2a receptors on the PBelCGRP neurons.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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