Discovery of a Selective NEK6 Kinase Inhibitor by Virtual Screening

Affiliations

Benedetta Righino: Institute of Biochemistry and Clinical Biochemistry, Università Cattolica del Sacro Cuore, 00198 Rome, Italy
Marta De Donato: Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Flavia Filippetti: Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Alessandra Battaglia: Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Marco Petrillo: Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Davide Pirolli: Institute of Chemistry of Molecular Recognition (ICRM)—CNR, 00185 Rome, Italy
Giovanni Scambia: Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Daniela Gallo: Institute of Obstetrics and Gynecology, Università Cattolica del Sacro Cuore, 00168 Rome, Italy
Maria Cristina De Rosa: Institute of Chemistry of Molecular Recognition (ICRM)—CNR, 00185 Rome, Italy

Abstract

NIMA-related kinases (Neks) are a conserved serine/threonine protein kinase family related tocell cycle progression and cell division [...]