Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

Ricardo M. Gouveia; Guillaume Lepert; Suneel Gupta; Rajiv R. Mohan; Carl Paterson; Che J. Connon

doi:10.1038/s41467-019-09331-6

Nature Communications (Apr 2019)

Assessment of corneal substrate biomechanics and its effect on epithelial stem cell maintenance and differentiation

Ricardo M. Gouveia,
Guillaume Lepert,
Suneel Gupta,
Rajiv R. Mohan,
Carl Paterson,
Che J. Connon

Affiliations

Ricardo M. Gouveia: Institute of Genetic Medicine, Newcastle University, International Centre for Life
Guillaume Lepert: The Blackett Laboratory, Imperial College London
Suneel Gupta: Harry S. Truman Memorial Veterans Hospital
Rajiv R. Mohan: Harry S. Truman Memorial Veterans Hospital
Carl Paterson: The Blackett Laboratory, Imperial College London
Che J. Connon: Institute of Genetic Medicine, Newcastle University, International Centre for Life

DOI: https://doi.org/10.1038/s41467-019-09331-6
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 17

Abstract

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The link between how the stiffness of the cornea affects stem cells is unclear. Here, the authors use Brillouin spectro-microscopy to show that mechanical properties of the cornea affect epithelial stem cells and after injury, treating the cornea with collagenase suppresses YAP activation, assisting in regeneration.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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