Nature Communications (Sep 2021)

Reconstitution defines the roles of p62, NBR1 and TAX1BP1 in ubiquitin condensate formation and autophagy initiation

  • Eleonora Turco,
  • Adriana Savova,
  • Flora Gere,
  • Luca Ferrari,
  • Julia Romanov,
  • Martina Schuschnig,
  • Sascha Martens

DOI
https://doi.org/10.1038/s41467-021-25572-w
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 16

Abstract

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Misfolded proteins are ubquitinated and subsequently condensed by cargo receptors for selective autophagy. Here, the authors use in vitro reconstitution to elegantly dissect how the receptors p62/SQSTM1, NBR1 and TAX1BP1 contribute to p62-ubiquitin condensate formation and degradation by autophagy.