Nature Communications (Mar 2023)

mRNA vaccines and hybrid immunity use different B cell germlines against Omicron BA.4 and BA.5

  • Emanuele Andreano,
  • Ida Paciello,
  • Giulio Pierleoni,
  • Giuseppe Maccari,
  • Giada Antonelli,
  • Valentina Abbiento,
  • Piero Pileri,
  • Linda Benincasa,
  • Ginevra Giglioli,
  • Giulia Piccini,
  • Concetta De Santi,
  • Claudia Sala,
  • Duccio Medini,
  • Emanuele Montomoli,
  • Piet Maes,
  • Rino Rappuoli

Journal volume & issue
Vol. 14, no. 1
pp. 1 – 9


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Omicron strains of SARS-CoV-2 have displayed high transmissibility and immunological escape to antibody responses derived from natural infection and vaccination. Here the authors compare the antibody response to vaccination and natural infection, assessing neutralisation after vaccine doses and analyse the repertoire of such responses.