Diabetes, Metabolic Syndrome and Obesity (Apr 2023)
Differences and Clinical Significance of Serum 25-Hydroxyvitamin D3 and Vasohibin-1 (VASH-1) Levels in Patients with Diabetic Nephropathy and Different Renal Injuries
Abstract
Hui Liu,1 Dongyan Wang,1 Jingnan Tang,1 Linlin Yu,2 Shanshan Su1 1Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China; 2Department of Science and Technology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of ChinaCorrespondence: Shanshan Su, Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China, Email [email protected]: We investigate the relationship between the changes of serum 25-hydroxyvitamin D3 (25(OH)D3) and vasohibin-1 (VASH-1) and renal function injury in patients with type 2 diabetic nephropathy.Methods: In this study, 143 patients with diabetic nephropathy (DN) were selected as DN group, and 80 patients with type 2 diabetes mellitus were selected as T2DM group. The serum 25 (OH) D3, VASH-1, blood glucose index, inflammation index and renal function index were compared between the two groups. According to the urinary microalbumin/creatinine ratio (UACR), the DN group was divided into microalbuminuria group (UACR range≥ 30.0mg/g and < 300.0mg/g) and macroalbuminuria group (UACR≥ 300.0mg/g) for stratified comparison. The correlation between 25-hydroxyvitamin D3, VASH-1 and inflammation index and renal function index was analyzed by simple linear correlation analysis.Results: The level of 25 (OH) D3 in DN group was significantly lower than that in T2DM group (P< 0.05). The levels of VASH-1, CysC, BUN, Scr, 24h urine protein, serum CRP, TGF-β 1, TNF-α and IL-6 in DN group were higher than those in T2DM group (P< 0.05). The level of 25 (OH) D3 in DN patients with massive proteinuria was significantly lower than that in DN patients with microalbuminuria. The level of VASH-1 in DN patients with massive proteinuria was higher than that in DN patients with microalbuminuria (P< 0.05). There was a negative correlation between 25 (OH) D3 and CysC, BUN, Scr, 24h urine protein, CRP, TGF-β 1, TNF-α, IL-6 in patients with DN (P< 0.05). VASH-1 was positively correlated with Scr, 24h urinary protein, CRP, TGF-β 1, TNF-α and IL-6 in patients with DN (P< 0.05).Conclusion: The level of serum 25 (OH) D3 in DN patients was considerably decreased, and the level of VASH-1 was increased, which was related to the degree of renal function injury and inflammatory response.Keywords: 25 hydroxyvitamin D3, angiogenesis inhibitor protein 1, type 2 diabetes, diabetic nephropathy, renal function damage, inflammation indicators
