Cancer Cell International (Feb 2023)

MicroRNA-122 in human cancers: from mechanistic to clinical perspectives

  • Mahboobeh Faramin Lashkarian,
  • Nasrin Hashemipour,
  • Negin Niaraki,
  • Shahrad Soghala,
  • Ali Moradi,
  • Sareh Sarhangi,
  • Mahsa Hatami,
  • Fatemehsadat Aghaei-Zarch,
  • Mina Khosravifar,
  • Alireza Mohammadzadeh,
  • Sajad Najafi,
  • Jamal Majidpoor,
  • Poopak Farnia,
  • Seyed Mohsen Aghaei-Zarch

DOI
https://doi.org/10.1186/s12935-023-02868-z
Journal volume & issue
Vol. 23, no. 1
pp. 1 – 25

Abstract

Read online

Abstract MicroRNAs (miRNAs) are endogenous short non-coding RNAs that can regulate the expression of target genes post-transcriptionally and interact with mRNA-coding genes. MiRNAs play vital roles in many biological functions, and abnormal miRNA expression has been linked to various illnesses, including cancer. Among the miRNAs, miR-122, miR-206, miR-21, miR-210, miR-223, and miR-424 have been extensively studied in various cancers. Although research in miRNAs has grown considerably over the last decade, much is yet to be discovered, especially regarding their role in cancer therapies. Several kinds of cancer have been linked to dysregulation and abnormal expression of miR-122, indicating that miR-122 may serve as a diagnostic and/or prognostic biomarker for human cancer. Consequently, in this review literature, miR-122 has been analyzed in numerous cancer types to sort out the function of cancer cells miR-122 and enhance patient response to standard therapy.

Keywords