The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Lijian Shao; Jianhui Chang; Wei Feng; Xiaoyan Wang; Elizabeth A. Williamson; Ying Li; Amir Schajnovitz; David Scadden; Luke J. Mortensen; Charles P. Lin; Linheng Li; Ariel Paulson; James Downing; Daohong Zhou; Robert A. Hromas

doi:10.1038/s41467-018-04716-5

Nature Communications (Jun 2018)

The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow

Lijian Shao,
Jianhui Chang,
Wei Feng,
Xiaoyan Wang,
Elizabeth A. Williamson,
Ying Li,
Amir Schajnovitz,
David Scadden,
Luke J. Mortensen,
Charles P. Lin,
Linheng Li,
Ariel Paulson,
James Downing,
Daohong Zhou,
Robert A. Hromas

Affiliations

Lijian Shao: Department of Pharmacology, University of Illinois Chicago
Jianhui Chang: Department of Pharmaceutical Sciences and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences
Wei Feng: Department of Pharmaceutical Sciences and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences
Xiaoyan Wang: Department of Pharmaceutical Sciences and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences
Elizabeth A. Williamson: Department of Medicine and Pathology, University of Florida
Ying Li: Department of Medicine and Pathology, University of Florida
Amir Schajnovitz: Stem Cell and Regenerative Biology Department, Harvard University
David Scadden: Stem Cell and Regenerative Biology Department, Harvard University
Luke J. Mortensen: Regenerative Medicine Center, University of Georgia
Charles P. Lin: Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School
Linheng Li: Department of Pathology and Laboratory, Medicine University of Kansas
Ariel Paulson: Department of Pathology and Laboratory, Medicine University of Kansas
James Downing: Department of Pathology and Laboratory Medicine, St. Jude Children’s Research Hospital
Daohong Zhou: Department of Pharmaceutical Sciences and Winthrop P. Rockefeller Cancer Institute, University of Arkansas for Medical Sciences
Robert A. Hromas: Office of the Dean and the Cancer Center, Long School of Medicine, University of Texas Health Science Center

DOI: https://doi.org/10.1038/s41467-018-04716-5
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 12

Abstract

Read online

Hematopoietic stem cells (HSCs) migrate from the fetal liver to the bone marrow (BM) during embryogenesis. Here the authors show that the WAVE2 complex scaffold Hem1 is required for engraftment of HSCs in BM, not through its canonical role regulating actin polymerization, but through c-Abl survival signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal