Nature Communications (Oct 2018)
Mrp1 is involved in lipid presentation and iNKT cell activation by Streptococcus pneumoniae
- Shilpi Chandra,
- James Gray,
- William B. Kiosses,
- Archana Khurana,
- Kaori Hitomi,
- Catherine M. Crosby,
- Ashu Chawla,
- Zheng Fu,
- Meng Zhao,
- Natacha Veerapen,
- Stewart K. Richardson,
- Steven A. Porcelli,
- Gurdyal Besra,
- Amy R. Howell,
- Sonia Sharma,
- Bjoern Peters,
- Mitchell Kronenberg
Affiliations
- Shilpi Chandra
- Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
- James Gray
- The Functional Genomics Center, La Jolla Institute for Allergy and Immunology
- William B. Kiosses
- Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
- Archana Khurana
- Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
- Kaori Hitomi
- Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
- Catherine M. Crosby
- Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
- Ashu Chawla
- Bioinformatics Core, La Jolla Institute for Allergy and Immunology
- Zheng Fu
- Bioinformatics Core, La Jolla Institute for Allergy and Immunology
- Meng Zhao
- Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
- Natacha Veerapen
- School of Biosciences, University of Birmingham
- Stewart K. Richardson
- Department of Chemistry, University of Connecticut
- Steven A. Porcelli
- Department of Microbiology and Immunology, and Department of Medicine, Albert Einstein College of Medicine
- Gurdyal Besra
- School of Biosciences, University of Birmingham
- Amy R. Howell
- Department of Chemistry, University of Connecticut
- Sonia Sharma
- The Functional Genomics Center, La Jolla Institute for Allergy and Immunology
- Bjoern Peters
- Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology
- Mitchell Kronenberg
- Division of Developmental Immunology, La Jolla Institute for Allergy and Immunology
- DOI
- https://doi.org/10.1038/s41467-018-06646-8
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
The CD1d pathway present lipid antigens resulting in the activation of iNKT cells but the complete pathway remains to be fully elucidated. Here, Chandra et al. use an siRNA screen and identify Mrp1 as crucial for CD1d lipid presentation and activation of iNKT in the context of Streptococcus pneumoniae infection.
