Nature Communications (Oct 2018)
Epigenomic map of human liver reveals principles of zonated morphogenic and metabolic control
- Mario Brosch,
- Kathrin Kattler,
- Alexander Herrmann,
- Witigo von Schönfels,
- Karl Nordström,
- Daniel Seehofer,
- Georg Damm,
- Thomas Becker,
- Sebastian Zeissig,
- Sophie Nehring,
- Fabian Reichel,
- Vincent Moser,
- Raghavan Veera Thangapandi,
- Felix Stickel,
- Gustavo Baretton,
- Christoph Röcken,
- Michael Muders,
- Madlen Matz-Soja,
- Michael Krawczak,
- Gilles Gasparoni,
- Hella Hartmann,
- Andreas Dahl,
- Clemens Schafmayer,
- Jörn Walter,
- Jochen Hampe
Affiliations
- Mario Brosch
- Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Kathrin Kattler
- Department of Genetics and Epigenetics, Universität des Saarlandes
- Alexander Herrmann
- Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Witigo von Schönfels
- Department of Visceral Surgery, University Hospital Schleswig-Holstein, Christian-Albrechts-University Kiel
- Karl Nordström
- Department of Genetics and Epigenetics, Universität des Saarlandes
- Daniel Seehofer
- Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig
- Georg Damm
- Department of Hepatobiliary Surgery and Visceral Transplantation, University of Leipzig
- Thomas Becker
- Department of Visceral Surgery, University Hospital Schleswig-Holstein, Christian-Albrechts-University Kiel
- Sebastian Zeissig
- Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Sophie Nehring
- Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Fabian Reichel
- Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Vincent Moser
- Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Raghavan Veera Thangapandi
- Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Felix Stickel
- Department of Gastroenterology, University of Zürich
- Gustavo Baretton
- Institute of Pathology, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Christoph Röcken
- Institute of Pathology, University Hospital Schleswig-Holstein, Christian-Albrechts-University Kiel
- Michael Muders
- Institute of Pathology, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- Madlen Matz-Soja
- Rudolf-Schönheimer-Institute for Biochemistry, University of Leipzig
- Michael Krawczak
- Institute of Medical Informatics and Statistics, Christian-Albrechts University
- Gilles Gasparoni
- Department of Genetics and Epigenetics, Universität des Saarlandes
- Hella Hartmann
- Center for Molecular and Cellular Bioengineering (CMCB), Technische Universität Dresden (TU Dresden)
- Andreas Dahl
- Center for Regenerative Therapies Dresden (CRTD), Technische Universität Dresden (TU Dresden)
- Clemens Schafmayer
- Department of Visceral Surgery, University Hospital Schleswig-Holstein, Christian-Albrechts-University Kiel
- Jörn Walter
- Department of Genetics and Epigenetics, Universität des Saarlandes
- Jochen Hampe
- Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden)
- DOI
- https://doi.org/10.1038/s41467-018-06611-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 11
Abstract
Spatial mapping of genomic programs in tissue cells is an important step in the understanding of organ function and disease. Here, the authors provide a spatially resolved epigenomic and transcriptomic map of human liver and show porto-central gradients in metabolic and morphogen networks and transcription factor binding sites as a basis to better understand liver regeneration and function.
