Validation of clinical tumor depth of invasion measure in patients with oral cavity cancer

Kelsey B. Wood; Lauren S. Buck; Charlotte S. Taylor; Johnny Yang; Edward Florez; Todd A. Nichols; Jeffrey D. Hooker; Candace M. Howard-Claudio; Anne C. Kane; Oishika Paul; Lana L. Jackson; Christopher Spankovich; Gina D. Jefferson

Oral Oncology Reports (Dec 2024)

Validation of clinical tumor depth of invasion measure in patients with oral cavity cancer

Kelsey B. Wood,
Lauren S. Buck,
Charlotte S. Taylor,
Johnny Yang,
Edward Florez,
Todd A. Nichols,
Jeffrey D. Hooker,
Candace M. Howard-Claudio,
Anne C. Kane,
Oishika Paul,
Lana L. Jackson,
Christopher Spankovich,
Gina D. Jefferson

Affiliations

Kelsey B. Wood: Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Lauren S. Buck: Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Charlotte S. Taylor: Department of Radiology, Neuroradiology Division, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Johnny Yang: School of Medicine, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Edward Florez: Department of Radiology, Neuroradiology Division, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Todd A. Nichols: Department of Radiology, Neuroradiology Division, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Jeffrey D. Hooker: Department of Radiology, Neuroradiology Division, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Candace M. Howard-Claudio: Department of Radiology, Neuroradiology Division, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Anne C. Kane: Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Oishika Paul: Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Lana L. Jackson: Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Christopher Spankovich: Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA
Gina D. Jefferson: Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State St., Jackson, MS, 39216, USA; Corresponding author. Department of Otolaryngology-Head and Neck Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.

Journal volume & issue: Vol. 12
p. 100667

Abstract

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Objectives: The 8th edition of the American Joint Committee on Cancer (AJCC) for head and neck malignancies incorporated depth of invasion (DOI) for oral cavity squamous cell carcinoma (OCSCC). Currently, there is no standardized method to determine clinical DOI (cDOI). We aim to validate radiologic DOI (rDOI) utilizing contrast-enhanced computed tomography (CECT) imaging. Materials and methods: Radiographic DOI was defined as the coronal measurement of the deepest margin parallel to the expected normal mucosal plane. To establish a valid, accurate and repeatable rDOI, a retrospective cohort at a single institution tertiary hospital underwent preoperative CECT. Radiographic DOI was independently assessed by 2 neuroradiologists. Correlation was determined between rDOI and pDOI. A prospective pilot study of 49 patients with newly diagnosed OCSCC underwent rDOI assessment compared to final pDOI to assess our rDOI method clinical applicability. Results: Neuroradiologists demonstrated a high degree of predictability between rDOI and pDOI with as great as 90.91 % accuracy for readable CECTs. Inter-observer correlations were strong in the retrospective (Session 1: ICC = 0.956; Session 2: ICC = 0.932) and prospective cohorts (Session 1: ICC = 0.859; Session 2: ICC = 0.913) illustrating reliability. Intraobserver correlations were also strong (Retrospective Reader 1 ICC = 0.968, Reader 2 ICC = 0.941; prospective Reader 1 ICC = 0.965, Reader 2 ICC = 0.800, p < 0.001). T1 lesions were immeasurable 25–62.5 % of the time. Conclusions: Using CECT, the coronal measurement of the deepest margin parallel to the expected normal mucosal plane can enhance determination of a reliable cDOI in OCSCC corresponding to pDOI without change in staging for T2 and greater lesions.

Published in Oral Oncology Reports

ISSN: 2772-9060 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.sciencedirect.com/journal/oral-oncology-reports

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