Nature Communications (Nov 2020)
Concordant peripheral lipidome signatures in two large clinical studies of Alzheimer’s disease
- Kevin Huynh,
- Wei Ling Florence Lim,
- Corey Giles,
- Kaushala S. Jayawardana,
- Agus Salim,
- Natalie A. Mellett,
- Adam Alexander T. Smith,
- Gavriel Olshansky,
- Brian G. Drew,
- Pratishtha Chatterjee,
- Ian Martins,
- Simon M. Laws,
- Ashley I. Bush,
- Christopher C. Rowe,
- Victor L. Villemagne,
- David Ames,
- Colin L. Masters,
- Matthias Arnold,
- Kwangsik Nho,
- Andrew J. Saykin,
- Rebecca Baillie,
- Xianlin Han,
- Rima Kaddurah-Daouk,
- Ralph N. Martins,
- Peter J. Meikle
Affiliations
- Kevin Huynh
- Baker Heart and Diabetes Institute
- Wei Ling Florence Lim
- School of Medical and Health Sciences, Edith Cowan University
- Corey Giles
- Baker Heart and Diabetes Institute
- Kaushala S. Jayawardana
- Baker Heart and Diabetes Institute
- Agus Salim
- Baker Heart and Diabetes Institute
- Natalie A. Mellett
- Baker Heart and Diabetes Institute
- Adam Alexander T. Smith
- Baker Heart and Diabetes Institute
- Gavriel Olshansky
- Baker Heart and Diabetes Institute
- Brian G. Drew
- Baker Heart and Diabetes Institute
- Pratishtha Chatterjee
- School of Medical and Health Sciences, Edith Cowan University
- Ian Martins
- School of Medical and Health Sciences, Edith Cowan University
- Simon M. Laws
- School of Medical and Health Sciences, Edith Cowan University
- Ashley I. Bush
- The Florey Department of Neuroscience and Mental Health, The University of Melbourne
- Christopher C. Rowe
- The Florey Department of Neuroscience and Mental Health, The University of Melbourne
- Victor L. Villemagne
- Department of Nuclear Medicine and Centre for PET, Austin Health
- David Ames
- National Ageing Research Institute
- Colin L. Masters
- The Florey Department of Neuroscience and Mental Health, The University of Melbourne
- Matthias Arnold
- Department of Psychiatry and Behavioral Sciences, Duke University
- Kwangsik Nho
- Department of Radiology and Imaging Sciences, Indiana University School of Medicine
- Andrew J. Saykin
- Department of Radiology and Imaging Sciences, Indiana University School of Medicine
- Rebecca Baillie
- Rosa & Co LLC
- Xianlin Han
- Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio
- Rima Kaddurah-Daouk
- Department of Psychiatry and Behavioral Sciences, Duke University
- Ralph N. Martins
- School of Medical and Health Sciences, Edith Cowan University
- Peter J. Meikle
- Baker Heart and Diabetes Institute
- DOI
- https://doi.org/10.1038/s41467-020-19473-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 11
Abstract
The onset and pathology of Alzheimer’s disease (AD) is associated with changes to lipid metabolism. Here, the authors analysed 569 lipids from 32 classes and subclasses in two independent patient cohorts to identify key lipid pathways to link the plasma lipidome with AD and the future onset of AD.
