Frontiers in Endocrinology (Apr 2021)

Pathology Reporting in Neuroendocrine Neoplasms of the Digestive System: Everything You Always Wanted to Know but Were Too Afraid to Ask

  • Manuela Albertelli,
  • Manuela Albertelli,
  • Federica Grillo,
  • Federica Grillo,
  • Fabio Lo Calzo,
  • Fabio Lo Calzo,
  • Giulia Puliani,
  • Giulia Puliani,
  • Carmen Rainone,
  • Annamaria Anita Livia Colao,
  • Annamaria Anita Livia Colao,
  • Antongiulio Faggiano,
  • NIKE group,
  • Barbara Altieri,
  • Luigi Barrea,
  • Filomena Bottiglieri,
  • Severo Campione,
  • Federica De Cicco,
  • Sergio Di Molfetta,
  • Alessandra Dicitore,
  • Carlotta Dolci,
  • Tiziana Feola,
  • Giuseppe Fanciulli,
  • Diego Ferone,
  • Francesco Ferraù,
  • Marco Gallo,
  • Elisa Giannetta,
  • Erika Grossrubatscher,
  • Elia Guadagno,
  • Valentina Guarnotta,
  • Andrea M. Isidori,
  • Andrea Lania,
  • Andrea Lenzi,
  • Pasquale Malandrino,
  • Erika Messina,
  • Roberta Modica,
  • Giovanna Muscogiuri,
  • Luca Pes,
  • Genoveffa Pizza,
  • Riccardo Pofi,
  • Paola Razzore,
  • Laura Rizza,
  • Manila Rubino,
  • Rosa Maria Ruggieri,
  • Emilia Sbardella,
  • Franz Sesti,
  • Mary Anna Venneri,
  • Giovanni Vitale,
  • Maria Chiara Zatelli

DOI
https://doi.org/10.3389/fendo.2021.680305
Journal volume & issue
Vol. 12

Abstract

Read online

During the 5th NIKE (Neuroendocrine tumors Innovation in Knowledge and Education) meeting, held in Naples, Italy, in May 2019, discussions centered on the understanding of pathology reports of gastroenetropancreactic neuroendocrine neoplasms. In particular, the main problem concerned the difficulty that clinicians experience in extrapolating relevant information from neuroendocrine tumor pathology reports. During the meeting, participants were asked to identify and rate issues which they have encountered, for which the input of an expert pathologist would have been appreciated. This article is a collection of the most rated questions and relative answers, focusing on three main topics: 1) morphology and classification; 2) Ki67 and grading; 3) immunohistochemistry. Patient management should be based on multidisciplinary decisions, taking into account clinical and pathology-related features with clear comprehension between all health care professionals. Indeed, pathologists require clinical details and laboratory findings when relevant, while clinicians require concise and standardized reports. In keeping with this last statement, the minimum requirements in pathology datasets are provided in this paper and should be a baseline for all neuroendocrine tumor professionals.

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