Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8 +/− mouse model of ASD-like behavior

Abstract

The gut microbiota has been shown to modulate the neural function via the microbiota-gut-brain axis. Here, the authors show that Bacteroides uniformis, a gut commensal bacterium, restores the ASD-like phenotypes by reducing intestinal amino acid transport in an ASD mouse model.