Application of new targeted drugs in relapsed/refractory primary central nervous system lymphoma

Abstract

The prognosis of patients with relapsed and refractory primary central nervous system diffuse large B cell lymphoma (PCNSL) is poor and there is no standard salvage treatment currently available. Gene expression profiling and next-generation sequencing have provided massive amounts of data, revealing the pathogenic mechanism of PCNSL and identifying potential mechanisms for therapeutic exploration. Here, we review targeted drugs that may change the current treatment model of PCNSL.

Keywords

• pcnsl
• relapsed and refractory
• btk inhibitors
• pi3  k/mtor inhibitors
• immunomodulators
• immune checkpoint inhibitors