Bv8-Like Toxin from the Frog Venom of <i>Amolops jingdongensis</i> Promotes Wound Healing via the Interleukin-1 Signaling Pathway
Jiajia Chang,
Xiaoqin He,
Jingmei Hu,
Peter Muiruri Kamau,
Ren Lai,
Dingqi Rao,
Lei Luo
Affiliations
Jiajia Chang
College of Life Sciences, Anhui Normal University, Wuhu 241000, China
Xiaoqin He
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, National & Local Joint Engineering Laboratory of Natural Peptides, Kunming Institute of Zoology, Kunming 650223, China
Jingmei Hu
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, National & Local Joint Engineering Laboratory of Natural Peptides, Kunming Institute of Zoology, Kunming 650223, China
Peter Muiruri Kamau
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, National & Local Joint Engineering Laboratory of Natural Peptides, Kunming Institute of Zoology, Kunming 650223, China
Ren Lai
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, National & Local Joint Engineering Laboratory of Natural Peptides, Kunming Institute of Zoology, Kunming 650223, China
Dingqi Rao
State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China
Lei Luo
Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, National & Local Joint Engineering Laboratory of Natural Peptides, Kunming Institute of Zoology, Kunming 650223, China
Prokineticins are highly conserved small peptides family expressed in all vertebrates, which contain a wide spectrum of functions. In this study, a prokineticin homolog (Bv8-AJ) isolated from the venom of frog Amolops jingdongensis was fully characterized. Bv8-AJ accelerated full-thickness wounds healing of mice model by promoting the initiation and the termination of inflammatory phase. Moreover, Bv8-AJ exerted strong proliferative effect on fibroblasts and keratinocytes isolated from newborn mice by activating interleukin (IL)-1 production. Our findings indicate that Bv8 is a potent wound healing regulator and may reveal the mechanism of rapid wound-healing in amphibian skins.
