Introduction: Hospitalization may cause changes in physical and functional capabilities of patients. Objectives: To identify the effects of hospitalization on functional capacity and quality of life of cardiometabolic patients. Methods: Ten patients were evaluated in two periods (Collection 1: hospitalization and Collection 2: discharge), and the variables were grip strength, reaction speed, static balance test, aerobic fitness, physical activity index, index of daily living activities and quality of life evaluation. Results: The hospitalization caused decline in variables, handgrip strength and reaction speed, however the activities of daily living and quality of life showed improvement. Conclusions: The findings identify the limitations of clinics in regard to comprehensive care, thus confirming the need for an expanded approach to health care in hospital practices.