Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions

Tomoyuki Murakami; Jiwon Kim; Yi Li; Glenn Edward Green; Ariella Shikanov; Akira Ono

doi:10.1038/s41467-018-04846-w

Nature Communications (Jun 2018)

Secondary lymphoid organ fibroblastic reticular cells mediate trans-infection of HIV-1 via CD44-hyaluronan interactions

Tomoyuki Murakami,
Jiwon Kim,
Yi Li,
Glenn Edward Green,
Ariella Shikanov,
Akira Ono

Affiliations

Tomoyuki Murakami: Department of Microbiology and Immunology, University of Michigan Medical School
Jiwon Kim: Department of Macromolecular Science and Engineering, University of Michigan
Yi Li: Department of Macromolecular Science and Engineering, University of Michigan
Glenn Edward Green: Department of Otolaryngology-Head and Neck Surgery, University of Michigan Medical School
Ariella Shikanov: Department of Macromolecular Science and Engineering, University of Michigan
Akira Ono: Department of Microbiology and Immunology, University of Michigan Medical School

DOI: https://doi.org/10.1038/s41467-018-04846-w
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 14

Abstract

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Fibroblastic reticular cells (FRCs) are important regulators of T cell survival, proliferation, and migration in secondary lymphoid organs, but their role in HIV infection isn’t studied. Here, Murakami et al. show that FRCs enhance HIV spread via CD44- and hyaluronan-mediated trans-infection.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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