A magneto-optical biochip for rapid assay based on the Cotton–Mouton effect of γ-Fe2O3@Au core/shell nanoparticles

Abstract

Highlights 1. We developed a biochip for rapid assay based on the magneto-optical Cotton–Mouton (CM) effect of γ-Fe2O3@Au core/shell magnetic nanoparticles. 2. The easy and quick assay for detection of the spike glycoprotein S of SARS-CoV-2 was demonstrated, and whole process takes approximately 50 min including 3 min for the CM rotation measurement with the detection limit of 0.27 ng/mL (3.4 pM). 3. This magneto-optical biochip we proposed can be easily modified to use as assays for other diseases.

Keywords

• Biochip
• Cotton–Mouton (CM) effect
• Nanoparticles
• SARS-CoV-2
• COVID-19