Study of Tissue Cyst Formation Time of Toxoplasma gondii in Mice

Abstract

The purpose of the research was to study a tissue cyst formation time Toxoplasma gondii experimentally. A number of 84 mice were divided randomly into four groups. Each group consisted of 21 mice. The mice of the group I were infected with 10 1 , II with 10 2 and III with 10 tachyzoites respectively intraperitoneally, whereas the group IV as a control (not infected with tachyzoites). All infected mice were treated with sulfadiazine, 15 mg/mouse per oral diluted in drinking water, for 5 days. On first until twenty first day after treatment one mouse of each group was necropsied. Liver, lymph, kidney, lung, heart, brain, or diaphragm muscle were then taken for histological preparations. Data on tissue cyst formation time was analysed descriptively. The research revealed that innoculation with tachyzoites 10 3 cyst could be found on day 14 th after infection of liver, 10 2 cyst was found on the 6 day of liver, in day 7 th in heart and brain on day 10 th of after infection, 10 3 cyst was found on day 4 th in heart and brain in day 7 th th in liver, day 6 after infection, while in the control dosage there is no formation similar to cyst found. Keywords: cyst, tissue, T. gondii, mice th 1