Preparation and In vitro Characterization of Alprazolam Extended- Release Tablets Using HPMC 4000cps

Abstract

The main aim of this study was preparation and evaluation of extended - release system of the anxiolytic substance. Alprazolam is a short-acting benzodiazepine with general properties similar to those of diazepam. Our studies focused on development of extended drug delivery system based on Hydroxy Propyl Methyl Cellulose (HPMC 4000cps) as retard agent and Polyvinylpyrrolidone (PVP k30) as binder using factorial design. All prepared matrix tablets were considered for physicochemical evaluation and drug content. In vitro release study of matrix tablets for all formulations has shown that HPMC is the main component in retarding of alprazolam in dissolution medium. The optimum formulation (30% HPMC 4000 and 10% PVP) with suitable release profile according to criteria of United State Pharmacopoeia has selected for stability studies according to ICH guidelines.

Keywords

• Alprazolam
• Hydroxy Propyl Methyl Cellulose (HPMC 4000cps)
• Drug release
• Factorial design