Tight Junctions, the Key Factor in Virus-Related Disease
Guofei Ding,
Qingyuan Shao,
Haiyan Yu,
Jiaqi Liu,
Yingchao Li,
Bin Wang,
Haotian Sang,
Dexin Li,
Aiying Bing,
Yanmeng Hou,
Yihong Xiao
Affiliations
Guofei Ding
Department of Fundamental Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an 271018, China
Qingyuan Shao
Department of Fundamental Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an 271018, China
Haiyan Yu
Reproductive Center, Taian Central Hospital, Tai’an 271000, China
Jiaqi Liu
Department of Fundamental Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an 271018, China
Yingchao Li
Department of Fundamental Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an 271018, China
Bin Wang
Department of Fundamental Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an 271018, China
Haotian Sang
Department of Fundamental Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an 271018, China
Dexin Li
Department of Fundamental Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an 271018, China
Aiying Bing
School of Basic Medicine, Shandong First Medical University and Shandong Academy of Medical Sciences, Tai’an 271016, China
Yanmeng Hou
Department of Fundamental Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an 271018, China
Yihong Xiao
Department of Fundamental Veterinary Medicine, College of Veterinary Medicine, Shandong Agricultural University, 61 Daizong Street, Tai’an 271018, China
Tight junctions (TJs) are highly specialized membrane structural domains that hold cells together and form a continuous intercellular barrier in epithelial cells. TJs regulate paracellular permeability and participate in various cellular signaling pathways. As physical barriers, TJs can block viral entry into host cells; however, viruses use a variety of strategies to circumvent this barrier to facilitate their infection. This paper summarizes how viruses evade various barriers during infection by regulating the expression of TJs to facilitate their own entry into the organism causing infection, which will help to develop drugs targeting TJs to contain virus-related disease.
