Nature Communications (Jun 2016)

A Myc-driven self-reinforcing regulatory network maintains mouse embryonic stem cell identity

  • Luca Fagnocchi,
  • Alessandro Cherubini,
  • Hiroshi Hatsuda,
  • Alessandra Fasciani,
  • Stefania Mazzoleni,
  • Vittoria Poli,
  • Valeria Berno,
  • Riccardo L. Rossi,
  • Rolland Reinbold,
  • Max Endele,
  • Timm Schroeder,
  • Marina Rocchigiani,
  • Żaneta Szkarłat,
  • Salvatore Oliviero,
  • Stephen Dalton,
  • Alessio Zippo

DOI
https://doi.org/10.1038/ncomms11903
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 17

Abstract

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The Myc transcription factor is a major regulator of stem cell (SC) self-renewal and pluripotency but how this integrates signals from other pathways is unclear. Here, the authors show that Myc activation triggers epigenetic memory in self renewing embryonic SCs via PRC2-mediated potentiation of the Wnt pathway.