Silencing Nfix rescues muscular dystrophy by delaying muscle regeneration

Giuliana Rossi; Chiara Bonfanti; Stefania Antonini; Mattia Bastoni; Stefania Monteverde; Anna Innocenzi; Marielle Saclier; Valentina Taglietti; Graziella Messina

doi:10.1038/s41467-017-01098-y

Nature Communications (Oct 2017)

Silencing Nfix rescues muscular dystrophy by delaying muscle regeneration

Giuliana Rossi,
Chiara Bonfanti,
Stefania Antonini,
Mattia Bastoni,
Stefania Monteverde,
Anna Innocenzi,
Marielle Saclier,
Valentina Taglietti,
Graziella Messina

Affiliations

Giuliana Rossi: Department of Biosciences, University of Milan
Chiara Bonfanti: Department of Biosciences, University of Milan
Stefania Antonini: Department of Biosciences, University of Milan
Mattia Bastoni: Department of Biosciences, University of Milan
Stefania Monteverde: Department of Biosciences, University of Milan
Anna Innocenzi: Division of Regenerative Medicine, Stem Cells and Gene Therapy, San Raffaele Scientific Institute
Marielle Saclier: Department of Biosciences, University of Milan
Valentina Taglietti: Department of Biosciences, University of Milan
Graziella Messina: Department of Biosciences, University of Milan

DOI: https://doi.org/10.1038/s41467-017-01098-y
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 12

Abstract

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Strategies aimed at promoting muscle regeneration to treat muscular dystrophy have met with limited success. Here the authors show instead that delaying muscle regeneration, by ablation of the transcription factor Nfix, ameliorates muscular dystrophy in mice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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