Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain

Chun Chieh Fan; Robert Loughnan; Carolina Makowski; Diliana Pecheva; Chi-Hua Chen; Donald J. Hagler; Wesley K. Thompson; Nadine Parker; Dennis van der Meer; Oleksandr Frei; Ole A. Andreassen; Anders M. Dale

doi:10.1038/s41467-022-30110-3

Nature Communications (May 2022)

Multivariate genome-wide association study on tissue-sensitive diffusion metrics highlights pathways that shape the human brain

Chun Chieh Fan,
Robert Loughnan,
Carolina Makowski,
Diliana Pecheva,
Chi-Hua Chen,
Donald J. Hagler,
Wesley K. Thompson,
Nadine Parker,
Dennis van der Meer,
Oleksandr Frei,
Ole A. Andreassen,
Anders M. Dale

Affiliations

Chun Chieh Fan: Population Neuroscience and Genetics Lab, University of California, San Diego
Robert Loughnan: Department of Cognitive Science, University of California, San Diego
Carolina Makowski: Center for Multimodal Imaging and Genetics, University of California, San Diego
Diliana Pecheva: Center for Multimodal Imaging and Genetics, University of California, San Diego
Chi-Hua Chen: Department of Radiology, School of Medicine, University of California, San Diego
Donald J. Hagler: Center for Multimodal Imaging and Genetics, University of California, San Diego
Wesley K. Thompson: Population Neuroscience and Genetics Lab, University of California, San Diego
Nadine Parker: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Dennis van der Meer: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Oleksandr Frei: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Ole A. Andreassen: NORMENT Centre, Division of Mental Health and Addiction, Oslo University Hospital & Institute of Clinical Medicine, University of Oslo
Anders M. Dale: Center for Multimodal Imaging and Genetics, University of California, San Diego

DOI: https://doi.org/10.1038/s41467-022-30110-3
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

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How the tissue composition of the human brain is determined remains unclear. Here, the authors apply advanced analyses to two large imaging genetic datasets to identify and validate genetic loci that simultaneously influence multiple brain regions.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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