Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division

Sylvain Loubéry; Alicia Daeden; Carole Seum; Laurent Holtzer; Ana Moraleda; Nicolas Damond; Emmanuel Derivery; Thomas Schmidt; Marcos Gonzalez-Gaitan

doi:10.1038/ncomms15285

Nature Communications (Jun 2017)

Sara phosphorylation state controls the dispatch of endosomes from the central spindle during asymmetric division

Sylvain Loubéry,
Alicia Daeden,
Carole Seum,
Laurent Holtzer,
Ana Moraleda,
Nicolas Damond,
Emmanuel Derivery,
Thomas Schmidt,
Marcos Gonzalez-Gaitan

Affiliations

Sylvain Loubéry: Department of Biochemistry, University of Geneva
Alicia Daeden: Department of Biochemistry, University of Geneva
Carole Seum: Department of Biochemistry, University of Geneva
Laurent Holtzer: Department of Biochemistry, University of Geneva
Ana Moraleda: Department of Biochemistry, University of Geneva
Nicolas Damond: Department of Biochemistry, University of Geneva
Emmanuel Derivery: Department of Biochemistry, University of Geneva
Thomas Schmidt: Department of Biochemistry, University of Geneva
Marcos Gonzalez-Gaitan: Department of Biochemistry, University of Geneva

DOI: https://doi.org/10.1038/ncomms15285
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 11

Abstract

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Asymmetric segregation of cell fate determinants during cell division governs daughter cell fate. Here the authors show that Sara endosomes, known to regulate Notch signalling, are targeted to the mitotic spindle and once phosphorylated are asymmetrically dispatched into a daughter cell to determine cell fate.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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