Interactions between Radiation and One-Carbon Metabolism

Abstract

Metabolic reprogramming is a hallmark of cancer. Cancer cells rewire one-carbon metabolism, a central metabolic pathway, to turn nutritional inputs into essential biomolecules required for cancer cell growth and maintenance. Radiation therapy, a common cancer therapy, also interacts and alters one-carbon metabolism. This review discusses the interactions between radiation therapy, one-carbon metabolism and its component metabolic pathways.

Keywords

• one-carbon metabolism
• radiation therapy
• cancer therapy
• folate cycle
• methionine cycle