Nature Communications (Aug 2016)
Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming
Abstract
Reactivation of the inactive X chromosome (Xi) has modelled epigenetic reprogramming in mouse. Here, by using cell fusion between human female fibroblasts and mouse embryonic stem cells, the authors show a complex hierarchy of epigenetic changes that are required to reactivate the genes on the human Xi chromosome.