Nature Communications (Aug 2016)

Ordered chromatin changes and human X chromosome reactivation by cell fusion-mediated pluripotent reprogramming

  • Irene Cantone,
  • Hakan Bagci,
  • Dirk Dormann,
  • Gopuraja Dharmalingam,
  • Tatyana Nesterova,
  • Neil Brockdorff,
  • Claire Rougeulle,
  • Celine Vallot,
  • Edith Heard,
  • Ronan Chaligne,
  • Matthias Merkenschlager,
  • Amanda G. Fisher

DOI
https://doi.org/10.1038/ncomms12354
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 12

Abstract

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Reactivation of the inactive X chromosome (Xi) has modelled epigenetic reprogramming in mouse. Here, by using cell fusion between human female fibroblasts and mouse embryonic stem cells, the authors show a complex hierarchy of epigenetic changes that are required to reactivate the genes on the human Xi chromosome.