Nature Communications (Jan 2019)
Cross-species genomic landscape comparison of human mucosal melanoma with canine oral and equine melanoma
- Kim Wong,
- Louise van der Weyden,
- Courtney R. Schott,
- Alastair Foote,
- Fernando Constantino-Casas,
- Sionagh Smith,
- Jane M. Dobson,
- Elizabeth P. Murchison,
- Hong Wu,
- Iwei Yeh,
- Douglas R. Fullen,
- Nancy Joseph,
- Boris C. Bastian,
- Rajiv M. Patel,
- Inigo Martincorena,
- Carla Daniela Robles-Espinoza,
- Vivek Iyer,
- Marieke L. Kuijjer,
- Mark J. Arends,
- Thomas Brenn,
- Paul W. Harms,
- Geoffrey A. Wood,
- David J. Adams
Affiliations
- Kim Wong
- Wellcome Sanger Institute, Wellcome Trust Genome Campus
- Louise van der Weyden
- Wellcome Sanger Institute, Wellcome Trust Genome Campus
- Courtney R. Schott
- Department of Pathobiology, University of Guelph
- Alastair Foote
- Rossdales Equine Hospital and Diagnostic Centre, High Street
- Fernando Constantino-Casas
- Department of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge
- Sionagh Smith
- The Royal (Dick) School of Veterinary Studies and The Roslin Institute, Easter Bush Campus
- Jane M. Dobson
- Department of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge
- Elizabeth P. Murchison
- Department of Veterinary Medicine, Cambridge Veterinary School, University of Cambridge
- Hong Wu
- Departments of Dermatology and Pathology, University of California
- Iwei Yeh
- Departments of Dermatology and Pathology, University of California
- Douglas R. Fullen
- Departments of Pathology and Dermatology, University of Michigan Medical School
- Nancy Joseph
- Departments of Dermatology and Pathology, University of California
- Boris C. Bastian
- Departments of Dermatology and Pathology, University of California
- Rajiv M. Patel
- Departments of Pathology and Dermatology, University of Michigan Medical School
- Inigo Martincorena
- Wellcome Sanger Institute, Wellcome Trust Genome Campus
- Carla Daniela Robles-Espinoza
- Wellcome Sanger Institute, Wellcome Trust Genome Campus
- Vivek Iyer
- Wellcome Sanger Institute, Wellcome Trust Genome Campus
- Marieke L. Kuijjer
- Department of Biostatistics, Harvard T.H. Chan School of Public Health
- Mark J. Arends
- University of Edinburgh, Division of Pathology, Centre for Comparative Pathology, Cancer Research UK Edinburgh Centre, Institute of Genetics & Molecular Medicine, Western General Hospital, Crewe Road South
- Thomas Brenn
- Wellcome Sanger Institute, Wellcome Trust Genome Campus
- Paul W. Harms
- Departments of Pathology and Dermatology, University of Michigan Medical School
- Geoffrey A. Wood
- Department of Pathobiology, University of Guelph
- David J. Adams
- Wellcome Sanger Institute, Wellcome Trust Genome Campus
- DOI
- https://doi.org/10.1038/s41467-018-08081-1
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 14
Abstract
Mucosal melanoma is a rare melanoma subtype that is poorly characterised. Here, the authors sequenced human, canine, and equine melanoma samples and performed a cross-species analysis, which revealed candidate driver genes, recurrent copy number alterations in regions syntenic between species, extensive intra-tumour heterogeneity and potential germline predisposing alleles
