Stereoselective cyclo-addition reactions of azomethine ylides catalysed by in situ generated Ag(I)/bisphosphine complexes

Abstract

Stereoselective cyclo-addition reactions of azomethine ylides promoted by in situ generated Ag(I)/bisphosphine complexes were studied. Under the optimised conditions, the pyrrolidine products were isolated in up to 84 % yield and with up to 71 % e.e. The effects of various reaction variables on the stereoselectivity were also investigated.

Keywords

• azomethine ylides
• stereoselectivity
• chiral phosphine
• Ag(I)