Nature Communications (May 2021)

Hierarchical progressive learning of cell identities in single-cell data

  • Lieke Michielsen,
  • Marcel J. T. Reinders,
  • Ahmed Mahfouz

DOI
https://doi.org/10.1038/s41467-021-23196-8
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 12

Abstract

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Classification methods for scRNA-seq data are limited in their ability to learn from multiple datasets simultaneously. Here the authors present scHPL, a hierarchical progressive learning method that automatically finds relationships between cell populations across multiple datasets and constructs a classification tree.