Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

Salvatore Zaffina; Eva Piano Mortari; Reparata Rosa Di Prinzio; Marco Cappa; Antonio Novelli; Emanuele Agolini; Massimiliano Raponi; Bruno Dallapiccola; Franco Locatelli; Franco Locatelli; Carlo Federico Perno; Rita Carsetti; Rita Carsetti

doi:10.3389/fimmu.2022.869042

Frontiers in Immunology (Apr 2022)

Case Report: Precision COVID-19 Immunization Strategy to Overcome Individual Fragility: A Case of Generalized Lipodystrophy Type 4

Salvatore Zaffina,
Eva Piano Mortari,
Reparata Rosa Di Prinzio,
Marco Cappa,
Antonio Novelli,
Emanuele Agolini,
Massimiliano Raponi,
Bruno Dallapiccola,
Franco Locatelli,
Franco Locatelli,
Carlo Federico Perno,
Rita Carsetti,
Rita Carsetti

Affiliations

Salvatore Zaffina: Occupational Medicine/Health Technology Assessment and Safety Research Unit, Clinical-Technological Innovations Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Eva Piano Mortari: Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Reparata Rosa Di Prinzio: Occupational Medicine/Health Technology Assessment and Safety Research Unit, Clinical-Technological Innovations Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Marco Cappa: Unit of Endocrinology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Antonio Novelli: Laboratory of Medical Genetics, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Emanuele Agolini: Laboratory of Medical Genetics, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Massimiliano Raponi: Medical Direction, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Bruno Dallapiccola: Genetics and Rare Diseases Research Division, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Franco Locatelli: Department of Pediatric Hematology and Oncology, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Franco Locatelli: Sapienza, University of Rome, Rome, Italy
Carlo Federico Perno: Microbiology and Diagnostic Immunology Unit and Multimodal Medicine Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Rita Carsetti: Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy
Rita Carsetti: Microbiology and Diagnostic Immunology Unit and Multimodal Medicine Research Area, Bambino Gesù Children’s Hospital, IRCCS, Rome, Italy

DOI: https://doi.org/10.3389/fimmu.2022.869042
Journal volume & issue: Vol. 13

Abstract

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A 48-year-old patient affected with congenital generalized lipodystrophy type 4 failed to respond to two doses of the BNT162b2 vaccine, consisting of lipid nanoparticle encapsulated mRNA. As the disease is caused by biallelic variants of CAVIN1, a molecule indispensable for lipid endocytosis and regulation, we complemented the vaccination cycle with a single dose of the Ad26.COV2 vaccine. Adenovirus-based vaccine entry is mediated by the interaction with adenovirus receptors and transport occurs in clathrin-coated pits. Ten days after Ad26.COV2 administration, S- and RBD-specific antibodies and high-affinity memory B cells increased significantly to values close to those observed in Health Care Worker controls.

Published in Frontiers in Immunology

ISSN: 1664-3224 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Immunologic diseases. Allergy
Website: http://journal.frontiersin.org/journal/immunology

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