Frontiers in Immunology (Apr 2022)
Persistence of SARS-CoV-2 Antibodies in Vaccinated Health Care Workers Analyzed by Coronavirus Antigen Microarray
- Sina Hosseinian,
- Kathleen Powers,
- Milind Vasudev,
- Anton M. Palma,
- Rafael de Assis,
- Aarti Jain,
- Peter Horvath,
- Paramveer S. Birring,
- Rana Andary,
- Connie Au,
- Brandon Chin,
- Ghali Khalil,
- Jenny Ventura,
- Madeleine K. Luu,
- Cesar Figueroa,
- Joshua M. Obiero,
- Emily Silzel,
- Rie Nakajima,
- William Thomas Gombrich,
- Algis Jasinskas,
- Frank Zaldivar,
- Frank Zaldivar,
- Sebastian Schubl,
- Sebastian Schubl,
- Philip L. Felgner,
- Saahir Khan,
- The Specimen Collection Group
Affiliations
- Sina Hosseinian
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Kathleen Powers
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Milind Vasudev
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Anton M. Palma
- Institute for Clinical and Translational Science, University of California Irvine, Irvine, CA, United States
- Rafael de Assis
- Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, United States
- Aarti Jain
- Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, United States
- Peter Horvath
- Institute for Clinical and Translational Science, University of California Irvine, Irvine, CA, United States
- Paramveer S. Birring
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Rana Andary
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Connie Au
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Brandon Chin
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Ghali Khalil
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Jenny Ventura
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Madeleine K. Luu
- School of Biological Sciences, University of California Irvine, Irvine, CA, United States
- Cesar Figueroa
- Department of Surgery, School of Medicine, University of California Irvine, Irvine, CA, United States
- Joshua M. Obiero
- Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, United States
- Emily Silzel
- Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, United States
- Rie Nakajima
- Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, United States
- William Thomas Gombrich
- School of Biological Sciences, University of California Irvine, Irvine, CA, United States
- Algis Jasinskas
- Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, United States
- Frank Zaldivar
- Institute for Clinical and Translational Science, University of California Irvine, Irvine, CA, United States
- Frank Zaldivar
- Department of Pediatrics, University of California Irvine, Irvine, CA, United States
- Sebastian Schubl
- School of Medicine, University of California Irvine, Irvine, CA, United States
- Sebastian Schubl
- Department of Surgery, School of Medicine, University of California Irvine, Irvine, CA, United States
- Philip L. Felgner
- Department of Physiology and Biophysics, University of California Irvine, Irvine, CA, United States
- Saahir Khan
- Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States
- The Specimen Collection Group
- School of Medicine, University of California Irvine, Irvine, CA, United States
- DOI
- https://doi.org/10.3389/fimmu.2022.817345
- Journal volume & issue
-
Vol. 13
Abstract
Recent studies provide conflicting evidence on the persistence of SARS-CoV-2 immunity induced by mRNA vaccines. Here, we aim to quantify the persistence of humoral immunity following vaccination using a coronavirus antigen microarray that includes 10 SARS-CoV-2 antigens. In a prospective longitudinal cohort of 240 healthcare workers, composite SARS-CoV-2 IgG antibody levels did not wane significantly over a 6-month study period. In the subset of the study population previously exposed to SARS-CoV-2 based on seropositivity for nucleocapsid antibodies, higher composite anti-spike IgG levels were measured before the vaccine but no significant difference from unexposed individuals was observed at 6 months. Age, vaccine type, or worker role did not significantly impact composite IgG levels, although non-significant trends towards lower antibody levels in older participants and higher antibody levels with Moderna vaccine were observed at 6 months. A small subset of our cohort were classified as having waning antibody titers at 6 months, and these individuals were less likely to work in patient care roles and more likely to have prior exposure to SARS-CoV-2.
Keywords
