Nature Communications (Apr 2019)

N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization

  • Federico Corti,
  • Yingdi Wang,
  • John M. Rhodes,
  • Deepak Atri,
  • Stephanie Archer-Hartmann,
  • Jiasheng Zhang,
  • Zhen W. Zhuang,
  • Dongying Chen,
  • Tianyun Wang,
  • Zhirui Wang,
  • Parastoo Azadi,
  • Michael Simons

DOI
https://doi.org/10.1038/s41467-019-09605-z
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 14

Abstract

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Proteoglycans are glycosylated proteins that play a number of structural and signalling functions. Here, Corti, Wang et al. show that the N-terminal sequence of proteoglycan Syndecan-2 selectively increases 6-O sulfation of its heparan sulfate chains, and that this promotes formation of a ternary Sdc2/VEGFA/VEGFR2 complex leading to increased angiogenesis.