The use of copper reagents on the base of copper (I) chloride for the synthesis of trans-3-substituted cyclic a-amino acids

Abstract

An efficient synthesis of 3-substituted cyclic amino acids via 1,4-conjugate addition of diorganocuprates to α,β-unsaturated cyclic α-aminoacids is described.The higher reactivity of copper reagents obtained from copper (I) chloride in comparison with CuCN, CuBr, CuI and CuBr*SMe2 has been shown