Metabolism as a biomarker for treatment success in anti-amyloid therapy: A case report

Kirk C. Wilhelmsen; Pierre-François D’Haese; Marc W. Haut; Gary D. Marano; Rashi I. Mehta; Xiaofei Wang; Melanie Ward; Mark Miller; Umer Najib; R. Osvaldo Navia; Cierra M. Keith; Ali Rezai

Neuroimage: Reports (Jun 2024)

Metabolism as a biomarker for treatment success in anti-amyloid therapy: A case report

Kirk C. Wilhelmsen,
Pierre-François D’Haese,
Marc W. Haut,
Gary D. Marano,
Rashi I. Mehta,
Xiaofei Wang,
Melanie Ward,
Mark Miller,
Umer Najib,
R. Osvaldo Navia,
Cierra M. Keith,
Ali Rezai

Affiliations

Kirk C. Wilhelmsen: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Departments of Neurology of West Virginia University, Morgantown, West Virginia, USA; Corresponding author. WVU Department of Neurology, WVU Rockefeller Neuroscience Institute, 33 Medical Center Drive, PO Box 9301, 26506, Morgantown, West Virginia, USA.
Pierre-François D’Haese: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Neuroradiology of West Virginia University, Morgantown, West Virginia, USA
Marc W. Haut: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Behavioral Medicine and Psychiatry of West Virginia University, Morgantown, West Virginia, USA
Gary D. Marano: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Radiology of West Virginia University, Morgantown, West Virginia, USA; Medicine of West Virginia University, Morgantown, West Virginia, USA
Rashi I. Mehta: Neuroradiology of West Virginia University, Morgantown, West Virginia, USA; Radiology of West Virginia University, Morgantown, West Virginia, USA
Xiaofei Wang: Radiology of West Virginia University, Morgantown, West Virginia, USA
Melanie Ward: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Departments of Neurology of West Virginia University, Morgantown, West Virginia, USA
Mark Miller: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Behavioral Medicine and Psychiatry of West Virginia University, Morgantown, West Virginia, USA
Umer Najib: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Departments of Neurology of West Virginia University, Morgantown, West Virginia, USA
R. Osvaldo Navia: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Medicine of West Virginia University, Morgantown, West Virginia, USA
Cierra M. Keith: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Behavioral Medicine and Psychiatry of West Virginia University, Morgantown, West Virginia, USA
Ali Rezai: Rockefeller Neuroscience Institute of West Virginia University, Morgantown, West Virginia, USA; Neurosurgery of West Virginia University, Morgantown, West Virginia, USA

Journal volume & issue: Vol. 4, no. 2
p. 100203

Abstract

Read online

This case report investigates the potential use of metabolism as a sensitive biomarker in monitoring the effectiveness of anti-amyloid therapy in a patient with mild cognitive impairment due to early Alzheimer's disease. The study centers around a 74-year-old male patient treated with aducanumab, a monoclonal antibody developed for anti-amyloid therapy. Alongside an expected decline in cerebral amyloid monitored using PET amyloid tracers, we observed significant improvements in the patient's brain metabolic activity, measured via 18-fluorodeoxyglucose positron emission tomography (FDG PET). Despite limitations posed by the single-patient case study, the findings invite further research and consider the utilization of FDG PET as a surrogate for clinically meaningful changes in the treatment of early Alzheimer's disease. These findings suggest the potential for more personalized and effective therapeutic interventions.

Published in Neuroimage: Reports

ISSN: 2666-9560 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neuroimage-reports

About the journal

Abstract

Keywords