Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives

Shanyu Lu; Shanyu Lu; Shanyu Lu; Zhenyu Liu; Zhenyu Liu; Zhenyu Liu; Meiling Qi; Meiling Qi; Meiling Qi; Yingchao Wang; Yingchao Wang; Le Chang; Le Chang; Xiaolong Bai; Xiaolong Bai; Yingguang Jiao; Yingguang Jiao; Xinyao Chen; Xinyao Chen; Junping Zhen; Junping Zhen; Junping Zhen

doi:10.3389/fcell.2024.1510390

Frontiers in Cell and Developmental Biology (Dec 2024)

Ferroptosis and its role in osteoarthritis: mechanisms, biomarkers, and therapeutic perspectives

Shanyu Lu,
Shanyu Lu,
Shanyu Lu,
Zhenyu Liu,
Zhenyu Liu,
Zhenyu Liu,
Meiling Qi,
Meiling Qi,
Meiling Qi,
Yingchao Wang,
Yingchao Wang,
Le Chang,
Le Chang,
Xiaolong Bai,
Xiaolong Bai,
Yingguang Jiao,
Yingguang Jiao,
Xinyao Chen,
Xinyao Chen,
Junping Zhen,
Junping Zhen,
Junping Zhen

Affiliations

Shanyu Lu: College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China
Shanyu Lu: Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Shanyu Lu: Shanxi Key Laboratory for Immunomicroecology, Taiyuan, Shanxi, China
Zhenyu Liu: College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China
Zhenyu Liu: Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Zhenyu Liu: Shanxi Key Laboratory for Immunomicroecology, Taiyuan, Shanxi, China
Meiling Qi: College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China
Meiling Qi: Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Meiling Qi: Shanxi Key Laboratory for Immunomicroecology, Taiyuan, Shanxi, China
Yingchao Wang: College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China
Yingchao Wang: Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Le Chang: College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China
Le Chang: Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Xiaolong Bai: College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China
Xiaolong Bai: Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Yingguang Jiao: College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China
Yingguang Jiao: Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Xinyao Chen: College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China
Xinyao Chen: Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Junping Zhen: College of Medical Imaging, Shanxi Medical University, Taiyuan, Shanxi, China
Junping Zhen: Department of Imaging, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
Junping Zhen: Molecular Imaging Laboratory, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi, China

DOI: https://doi.org/10.3389/fcell.2024.1510390
Journal volume & issue: Vol. 12

Abstract

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Osteoarthritis (OA) is one of the leading causes of disability worldwide, characterized by a complex pathological process involving cartilage degradation, synovial inflammation, and subchondral bone remodeling. In recent years, ferroptosis, a form of programmed cell death driven by iron-dependent lipid peroxidation, has been recognized as playing a critical role in the onset and progression of OA. Investigating the molecular mechanisms of ferroptosis and its involvement in OA may offer novel strategies for diagnosing and treating this disease. This review first outlines the core mechanisms of ferroptosis, with a particular focus on the roles of critical molecules such as Glutathione Peroxidase 4 (GPX4), Transferrin Receptor 1 (TfR1), and Nuclear Receptor Coactivator 4 (NCOA4). Subsequently, this study examines the specific impacts of ferroptosis on the pathophysiology of OA. Building on this, the potential of ferroptosis-related biomarkers for OA diagnosis and treatment is highlighted, along with proposed therapeutic strategies targeting ferroptosis regulation. This review aims to deepen the understanding of ferroptosis mechanisms and advance the clinical application of regulatory therapies for OA.

Published in Frontiers in Cell and Developmental Biology

ISSN: 2296-634X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: https://www.frontiersin.org/journals/cell-and-developmental-biology

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