Wound Modulations in Glaucoma Surgery: A Systematic Review

Abstract

Excessive fibrosis and resultant poor control of intraocular pressure (IOP) reduce the efficacy of glaucoma surgeries. Historically, corticosteroids and anti-fibrotic agents, such as mitomycin C (MMC) and 5-fluorouracil (5-FU), have been used to mitigate post-surgical fibrosis, but these have unpredictable outcomes. Therefore, there is a need to develop novel treatments which provide increased effectiveness and specificity. This review aims to provide insight into the pathophysiology behind wound healing in glaucoma surgery, as well as the current and promising future wound healing agents that are less toxic and may provide better IOP control.

Keywords

• glaucoma surgery
• wound healing
• antifibrotic agents
• anti-vascular endothelial growth factors
• cytokine inhibitors
• anti-LOXL2 monoclonal Ab