Triphenylphosphine dibromide: A useful reagent for conversion of aldoximes into nitriles

Abstract

A simple and convenient method for the synthesis of nitriles by dehydration of aldoximes has been developed using triphenylphosphine dibromide in acetonitrile at room temperature. A variety of aromatic and heteroaromatic aldoximes are converted into the corresponding nitriles in high yields.

Keywords

• Aldoxime
• Nitrile
• Dehydration
• Triphenylphosphine dibromide