Frontiers in Immunology (Nov 2020)
Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19
- Karel F. A. Van Damme,
- Karel F. A. Van Damme,
- Simon Tavernier,
- Simon Tavernier,
- Nele Van Roy,
- Elisabeth De Leeuw,
- Elisabeth De Leeuw,
- Jozefien Declercq,
- Jozefien Declercq,
- Cédric Bosteels,
- Cédric Bosteels,
- Bastiaan Maes,
- Bastiaan Maes,
- Marieke De Bruyne,
- Delfien Bogaert,
- Delfien Bogaert,
- Victor Bosteels,
- Victor Bosteels,
- Levi Hoste,
- Levi Hoste,
- Leslie Naesens,
- Leslie Naesens,
- Piet Maes,
- Alba Grifoni,
- Daniela Weiskopf,
- Alessandro Sette,
- Alessandro Sette,
- Pieter Depuydt,
- Pieter Depuydt,
- Eva Van Braeckel,
- Eva Van Braeckel,
- Filomeen Haerynck,
- Filomeen Haerynck,
- Bart N. Lambrecht,
- Bart N. Lambrecht,
- Bart N. Lambrecht,
- Bart N. Lambrecht
Affiliations
- Karel F. A. Van Damme
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Karel F. A. Van Damme
- Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium
- Simon Tavernier
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Simon Tavernier
- Unit of Molecular Signal Transduction in Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium
- Nele Van Roy
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Elisabeth De Leeuw
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Elisabeth De Leeuw
- Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium
- Jozefien Declercq
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Jozefien Declercq
- Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium
- Cédric Bosteels
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Cédric Bosteels
- Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium
- Bastiaan Maes
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Bastiaan Maes
- Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium
- Marieke De Bruyne
- Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium
- Delfien Bogaert
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Delfien Bogaert
- Primary Immunodeficiency Research Lab, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium
- Victor Bosteels
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Victor Bosteels
- Laboratory of ER Stress and Inflammation, VIB-UGent Center for Inflammation Research, Ghent, Belgium
- Levi Hoste
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Levi Hoste
- Primary Immunodeficiency Research Lab, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium
- Leslie Naesens
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Leslie Naesens
- Primary Immunodeficiency Research Lab, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium
- Piet Maes
- Department of Microbiology, Immunology, and Transplantation, Rega Institute for Medical Research, Division of Clinical and Epidemiological Virology, KU Leuven, Leuven, Belgium
- Alba Grifoni
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States
- Daniela Weiskopf
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States
- Alessandro Sette
- Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, CA, United States
- Alessandro Sette
- Department of Medicine, Division of Infectious Diseases and Global Public Health, University of California, San Diego (UCSD), CA, United States
- Pieter Depuydt
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Pieter Depuydt
- 0Department of Intensive Care, Ghent University Hospital, Ghent, Belgium
- Eva Van Braeckel
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Eva Van Braeckel
- 1Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
- Filomeen Haerynck
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Filomeen Haerynck
- Primary Immunodeficiency Research Lab, Jeffrey Modell Diagnosis and Research Center, Ghent University Hospital, Ghent, Belgium
- Bart N. Lambrecht
- Department of Internal Medicine and Pediatrics, Ghent University, Ghent, Belgium
- Bart N. Lambrecht
- Laboratory of Immunoregulation and Mucosal Immunology, VIB-UGent Center for Inflammation Research, Ghent, Belgium
- Bart N. Lambrecht
- 1Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
- Bart N. Lambrecht
- 2Department of Pulmonary Medicine, Erasmus Medical Center, Rotterdam, Netherlands
- DOI
- https://doi.org/10.3389/fimmu.2020.596761
- Journal volume & issue
-
Vol. 11
Abstract
The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient’s condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.
Keywords
- convalescent plasma
- COVID-19
- common variable immunodeficiency disorders
- immunodeficiencies
- case report
