Nature Communications (Jul 2017)
A point-of-care microfluidic biochip for quantification of CD64 expression from whole blood for sepsis stratification
- U. Hassan,
- T. Ghonge,
- B. Reddy Jr.,
- M. Patel,
- M. Rappleye,
- I. Taneja,
- A. Tanna,
- R. Healey,
- N. Manusry,
- Z. Price,
- T. Jensen,
- J. Berger,
- A. Hasnain,
- E. Flaugher,
- S. Liu,
- B. Davis,
- J. Kumar,
- K. White,
- R. Bashir
Affiliations
- U. Hassan
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- T. Ghonge
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- B. Reddy Jr.
- Micro and Nanotechnology Lab, University of Illinois at Urbana-Champaign
- M. Patel
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- M. Rappleye
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- I. Taneja
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- A. Tanna
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- R. Healey
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- N. Manusry
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- Z. Price
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- T. Jensen
- Biomedical Research Center, Carle Foundation Hospital
- J. Berger
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- A. Hasnain
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- E. Flaugher
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- S. Liu
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- B. Davis
- Biomedical Research Center, Carle Foundation Hospital
- J. Kumar
- Biomedical Research Center, Carle Foundation Hospital
- K. White
- Biomedical Research Center, Carle Foundation Hospital
- R. Bashir
- Department of Bioengineering, University of Illinois at Urbana-Champaign
- DOI
- https://doi.org/10.1038/ncomms15949
- Journal volume & issue
-
Vol. 8,
no. 1
pp. 1 – 12
Abstract
Sepsis is a potentially life–threatening complication of infection and diagnosis depends on rapid assessment of leukocyte count and CD64 expression. Here the authors present a microfluidic chip that can quantify these parameters from minimal amounts of whole blood with no manual processing.
