Nature Communications (Aug 2019)
Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker
Abstract
Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD). Here authors engineer tandem dimers of swapping-domains Shaker channels that allow distinguishing between VSD-to-PD far or near connections.