Nature Communications (Aug 2019)

Noncanonical mechanism of voltage sensor coupling to pore revealed by tandem dimers of Shaker

  • João L. Carvalho-de-Souza,
  • Francisco Bezanilla

DOI
https://doi.org/10.1038/s41467-019-11545-7
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Homotetrameric voltage-gated ion channels are assembled from individual subunits containing structurally distinct voltage sensor (VSD) and pore domains (PD). Here authors engineer tandem dimers of swapping-domains Shaker channels that allow distinguishing between VSD-to-PD far or near connections.