Frontiers in Cardiovascular Medicine (Sep 2021)
Oral Supplementation With Butyrate Improves Myocardial Ischemia/Reperfusion Injury via a Gut-Brain Neural Circuit
- Zhiyao Yu,
- Zhiyao Yu,
- Zhiyao Yu,
- Zhiyao Yu,
- Jiapeng Han,
- Jiapeng Han,
- Jiapeng Han,
- Jiapeng Han,
- Huaqiang Chen,
- Huaqiang Chen,
- Huaqiang Chen,
- Huaqiang Chen,
- Yueyi Wang,
- Yueyi Wang,
- Yueyi Wang,
- Yueyi Wang,
- Liping Zhou,
- Liping Zhou,
- Liping Zhou,
- Liping Zhou,
- Meng Wang,
- Meng Wang,
- Meng Wang,
- Meng Wang,
- Rong Zhang,
- Rong Zhang,
- Rong Zhang,
- Rong Zhang,
- Xiaoxing Jin,
- Xiaoxing Jin,
- Xiaoxing Jin,
- Xiaoxing Jin,
- Guocheng Zhang,
- Guocheng Zhang,
- Guocheng Zhang,
- Guocheng Zhang,
- Changyi Wang,
- Changyi Wang,
- Changyi Wang,
- Changyi Wang,
- Tianyou Xu,
- Tianyou Xu,
- Tianyou Xu,
- Tianyou Xu,
- Mengjie Xie,
- Mengjie Xie,
- Mengjie Xie,
- Mengjie Xie,
- Xiaofei Wang,
- Xiaofei Wang,
- Xiaofei Wang,
- Xiaofei Wang,
- Xiaoya Zhou,
- Xiaoya Zhou,
- Xiaoya Zhou,
- Xiaoya Zhou,
- Hong Jiang,
- Hong Jiang,
- Hong Jiang,
- Hong Jiang
Affiliations
- Zhiyao Yu
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Zhiyao Yu
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Zhiyao Yu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Zhiyao Yu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Jiapeng Han
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Jiapeng Han
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Jiapeng Han
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Jiapeng Han
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Huaqiang Chen
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Huaqiang Chen
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Huaqiang Chen
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Huaqiang Chen
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Yueyi Wang
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Yueyi Wang
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Yueyi Wang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Yueyi Wang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Liping Zhou
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Liping Zhou
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Liping Zhou
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Liping Zhou
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Meng Wang
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Meng Wang
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Meng Wang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Meng Wang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Rong Zhang
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Rong Zhang
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Rong Zhang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Rong Zhang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Xiaoxing Jin
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Xiaoxing Jin
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Xiaoxing Jin
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Xiaoxing Jin
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Guocheng Zhang
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Guocheng Zhang
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Guocheng Zhang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Guocheng Zhang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Changyi Wang
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Changyi Wang
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Changyi Wang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Changyi Wang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Tianyou Xu
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Tianyou Xu
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Tianyou Xu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Tianyou Xu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Mengjie Xie
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Mengjie Xie
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Mengjie Xie
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Mengjie Xie
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Xiaofei Wang
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Xiaofei Wang
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Xiaofei Wang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Xiaofei Wang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Xiaoya Zhou
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Xiaoya Zhou
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Xiaoya Zhou
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Xiaoya Zhou
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Hong Jiang
- Department of Cardiology, Renmin Hospital, Wuhan University, Wuhan, China
- Hong Jiang
- Cardiac Autonomic Nervous System Research Center, Wuhan University, Wuhan, China
- Hong Jiang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Hong Jiang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- DOI
- https://doi.org/10.3389/fcvm.2021.718674
- Journal volume & issue
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Vol. 8
Abstract
Objective: Butyrate, a short-chain fatty acid (SCFA) produced by the intestinal microbiota, plays a protective role in cardiovascular diseases (CVDs), but the mechanisms involved in this process remain unelucidated. We aimed to explore the effect of butyrate on myocardial ischemia/reperfusion (I/R) injury through the gut-brain neural circuit.Methods: Rats were randomly divided into four groups: sham group (sham), I/R group (I/R), I/R+ butyrate group (butyrate), and I/R+ butyrate+ vagotomy group (vagotomy). The rats were treated with sodium butyrate for 4 weeks, and the gut-brain neural circuit was investigated by subdiaphragmatic vagotomy.Results: Butyrate treatment significantly reduced the infarct size and decreased the expression of creatine kinase (CK), creatine kinase myocardial isoenzyme (CK-MB), and lactate dehydrogenase (LDH) compared with the values found for the I/R group. In addition, the I/R-induced increases in inflammation, oxidative stress, and apoptosis were attenuated by butyrate. However, the above-mentioned protective effects were diminished by subdiaphragmatic vagotomy. The RNA sequencing results also revealed that the butyrate-induced protective changes at the cardiac transcription level were reversed by vagotomy. An analysis of the heart rate variability (HRV) and the detection of norepinephrine (NE) showed that butyrate significantly inhibited the I/R-induced autonomic imbalance, but this inhibition was not observed in the vagotomy group. Butyrate treatment also suppressed the neural activity of the paraventricular nucleus (PVN) and superior cervical ganglion (SCG), and both of these effects were lost after vagotomy.Conclusions: Butyrate treatment significantly improves myocardial I/R injury via a gut-brain neural circuit, and this cardioprotective effect is likely mediated by suppression of the sympathetic nervous system.
Keywords
- short-chain fatty acid
- butyrate
- myocardial ischemia reperfusion injury
- gut-brain axis
- sympathetic nervous system