Clinical Pharmacology: Advances and Applications (Sep 2020)
Magnesium Sulfate Improves Some Risk Factors for Atherosclerosis in Patients Suffering from One or Two Coronary Artery Diseases: A Double-blind Clinical Trial Study
Abstract
Ali Reza Sobhani,1 Hossein Farshidi,2 Fariba Azarkish,3 Mahdiya Eslami,2 Ebrahim Eftekhar,4 Mansoor Keshavarz,5 Nepton Soltani6 1Clinical Pathology Department, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; 2Cardiovascular Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; 3Molecular Medicine Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; 4Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; 5Physiology Department, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran; 6Physiology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranCorrespondence: Nepton SoltaniPhysiology Department, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranTel +98 9133251067Fax +98 36688597Email [email protected]: Given the beneficial effect of MgSO4 on the cardiovascular system, this study was designed to investigate the effect of MgSO4 administration on suppressing some atherosclerotic risk factors in moderate coronary artery disease patients with one or two atherosclerotic vessels.Patients and Methods: In a randomized double-blind placebo-controlled clinical trial study, 64 patients with moderate coronary artery disease (55– 69% stenosis) were selected according to angiography findings. Patients were divided into four groups including patients with one or two atherosclerotic vessels treated with MgSO4 (Mg-treated-VR1, Mg-treated-VR2, respectively), placebo treated patients with one or two atherosclerotic vessels (Control-VR1, Control-VR2, respectively). The patients received either placebo or MgSO4 supplement capsule containing 300 mg MgSO4 for six months on a daily basis. ESR, Ca/Mg ratio, urine Mg level, serum Mg, fibrinogen, homocysteine, uric acid, Na, K, Ca, CRP, T3, T4, TSH, BUN, and Cr concentrations were measured at baseline and every three months.Results: Serum T3, Ca, K, homocysteine, CRP, and Mg concentrations were significantly improved in Mg-treated groups compared to placebo groups.Conclusion: The results of this study showed that despite the slight change in serum magnesium level, oral administration of MgSO4for six months could slightly reduce the serum levels of some inflammatory and vascular factors in moderate coronary artery disease patients.Keywords: atherosclerosis, MgSO4, fibrinogen, CRP, homocysteine, thyroid hormones
