INCREASED EXPRESSION OF AKR1C2 AND AKR1B1 GENES IS ASSOCIATED WITH THE DEVELOPMENT OF RESISTANCE TO DOCETAXEL IN PROSTATE CANCER

Abstract

Drug resistance is one of the most pressing issues in modern oncology and is a result of the combination of various molecular events in tumor cells under the influence of a drug, the full understanding of which is yet to be determined. The present study focused mainly on evaluating the expressionof genesfrom the aldo-keto reductase family during the development of chemoresistance in prostate cancer (PC) – one of the most common and socially significant types of cancer in men worldwide. Using transcriptomic profiling of a PC cell model during the development of resistance to the taxane docetaxel, a statistically significant increase in the expression of two genes from the aldo-keto reductase family, AKR1C2 and AKR1B1, was demonstrated, which was also confirmed by quantitative PCR. The obtained results emphasize the high potential of these genes for further research as promising markers of resistance, as well as therapeutic targets.

Keywords

• рак предстательной железы
• химиотерапия
• доцетаксел
• резистентность
• клеточная модель
• экспрессия
• prostate cancer
• chemotherapy
• docetaxel
• resistance
• cell model
• expression