This study aimed to examine the utility of inertial measurement unit (IMU) technology to identify angle, step-specific, and side-specific differences between youth soccer players with and without a history of lower limb injury during soccer-specific field tests. Thirty-two youths (mean age 16.4 years) who were elite soccer players (Females n = 13, Males n = 19) wore IMUs during pre- and postseason soccer-specific change-of-direction assessments. A response feature analysis was used to compare the change in peak resultant acceleration of the groups at a level of significance of p p = 0.012, ES = 1.0) and a 90° cut (p = 0.04, ES = 0.75) between the two groups. These data suggest that players with a history of lower limb injury might experience greater angle and side-specific change within a season in peak resultant acceleration when compared with injury-free athletes. This study demonstrates that IMUs may present a useful method to analyze youth soccer players’ change of direction movement after returning to play. These results can inform future studies investigating player monitoring and may prove to be a useful tool for coaches when designing individualized training programs in this population.