Nature Communications (Mar 2021)

Loss of Quaking RNA binding protein disrupts the expression of genes associated with astrocyte maturation in mouse brain

  • Kristina Sakers,
  • Yating Liu,
  • Lorida Llaci,
  • Scott M. Lee,
  • Michael J. Vasek,
  • Michael A. Rieger,
  • Sean Brophy,
  • Eric Tycksen,
  • Renate Lewis,
  • Susan E. Maloney,
  • Joseph D. Dougherty

DOI
https://doi.org/10.1038/s41467-021-21703-5
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 14

Abstract

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Quaking RNA binding protein (QKI) is known for its role in oligodendrocyte maturation. Here, the authors define the QKI targets in the mouse brain and show that loss of QKI disrupts the expression of cell maturation-associated genes in astrocytes in vivo.